As with any medicine, report any and all side effects, symptoms, or physical changes to your doctor.
In clinical studies in which Saizen HGH was given to children with growth hormone deficiency, the following reactions were infrequently seen: pain, numbness, redness, or swelling at the delivery site, hypothyroidism (low thyroid hormone), hypoglycemia (low blood sugar), seizures or convulsions, water retention, and worsening of psoriasis symptoms that existed before therapy began.
Any patient who has a growth hormone deficiency and does not respond to therapy should be tested for thyroid problems or antibodies to human growth hormone. Either of these conditions can reduce the effectiveness of the drug.
Leukemia has been reported in a small number of patients. It is not clear whether this is the result of the growth hormone deficiency itself, growth hormone therapy, or other associated treatments such as radiation therapy for brain tumors. So far, data has failed to confirm a relationship between growth hormone therapy and leukemia.
When growth hormone is given at the same site over a long period of time, the tissue can become damaged. This problem can be avoided by switching among several different sites (such as the thighs, rear end, abdomen, and backs of the arms).